- Rosmarinic Acid, Chinese Basil
A member of the mint family, perilla is used in a variety of Asian foods to add both flavor and color. It is also grown ornamentally in gardens.
The stem of the plant is used in Chinese medicine for treatment of morning sickness. The leaves are said to be helpful for asthma, colds and flus, and other lung problems.
What is Perilla Used for Today?
Recently, extracts of perilla have undergone study as a treatment for
(hay fever). Perilla contains high levels of the substance rosmarinic acid (also found in the herb rosemary and many other plants). Rosmarinic acid appears to have anti-inflammatory and anti-allergic actions.
In a 3-week double-blind, placebo-controlled study of 29 people with seasonal allergic rhinitis, participants were given one of three treatments: placebo,
extract enriched to contain 50 mg of rosmarinic acid, or an extract enhanced to contain 200 mg of rosmarinic acid.
The results showed that both perilla products reduced symptoms to a greater extent than placebo.
Animal studies hint that perilla might also be useful for a different type of allergy: the severe, rapid reaction known as anaphylaxis, commonly associated with shellfish, peanut, and bee-sting allergies.
Very weak evidence suggests that rosmarinic acid and/or perilla may have anti-cancer effects
and might also have benefits for
and other autoimmune diseases
as well as
A typical dosage of perilla should supply 50–200 mg of rosmarinic acid daily. Perilla also contains luteolin, a substance that may also have anti-allergic actions.
For this reason perilla products are often enriched with luteolin as well, typically providing 5–10 mg daily.
In the small clinical trials and animal studies conducted thus far, use of perilla and/or rosmarinic acid has not been associated with significant adverse effects. Due to the wide use of perilla in Asian cooking, as well as the prevalence of rosmarinic acid in many spices, these substances are assumed to have a relatively high level of safety. However, comprehensive safety testing has not been reported. Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
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extract in the murine two-stage skin model.
Youn J, Lee KH, Won J, et al. Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis.
Makino T, Ono T, Matsuyama K, et al. Suppressive effects of
on IgA nephropathy in HIGA mice.
Nephrol Dial Transplant
Takeda H, Tsuji M, Inazu M, et al. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice.
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