Calcium Channel Blockers
Examples of drugs in this family include:
- Amlodipine (Norvasc)
- Bepridil hydrochloride (Vascor)
- Diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Tiamate, Tiazac)
- Felodipine (Plendil)
- Isradipine (DynaCirc, DynaCirc CR)
- Nicardipine hydrochloride (Cardene, Cardene SR)
- Nifedipine (Procardia, Procardia XL, Adalat, Adalat CC)
- Nimodipine (Nimotop)
- Nisoldipine (Sular)
- Verapamil (Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan)
Taking calcium and vitamin D supplements might interfere with some of the effects of calcium channel-blockers.
According to a study in rats, ginkgo extract may cause the body to metabolize some calcium channel blockers more rapidly, thereby decreasing their effects.
8 Citrus Bioflavonoid
Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug.
This may necessitate a reduction in drug dosage.
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Br Med J (Clin Res Ed)
Hariman RJ, Mangiardi LM, McAllister RG Jr, et al. Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses.
Guadagnino V, Greengart A, Hollander G, et al. Treatment of severe left ventricular dysfunction with calcium chloride in patients receiving verapamil.
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Salerno DM, Anderson B, Sharkey PJ, et al. Intravenous verapamil for treatment of multifocal atrial tachycardia with and without calcium pretreatment.
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Luscher TF, Noll G, Sturmer T, et al. Calcium gluconate in severe verapamil intoxication.
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Orr GM, Bodansky HJ, Dymond DS, et al. Fatal verapamil overdose.
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Shinozuka K, Umegaki K, Kubota Y, et al. Feeding of
extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits.
Arch Pharm Res.